Warning: The circuit does not have ground (signal name = "GND")
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The simulator must set a signal to the potential 0 volt! This point of reference is necessary and obviously math. meaningful, since otherwise voltages e.g. V(Out) are not defined.
TARGET 3001! automatically selects (for the simulator) the signal with the name "GND", if it is present! This signal gets the new name "0" in the simulator (in the Target.Cir).
If the signal "GND" is missing, then a similar signal will be selected e.g. "AGND". An appropriate signal can be renamed to "GND", or also a GND reference symbol can be imported into the schematic, and so the signal gets automatically the name "GND", if you start the signal line at the pin of the GND reference symbol.
Exception: Pure digital circuits of course do not need ground.